Automated microplate handlers are laboratory equipment that simplifies many microplate-based experiments, which can be labor-intensive and susceptible to human error. These robotic instruments offer scientists both reproducibility and increased throughput. Many of these tools are broadly applicable to any plate-based task and some are specially designed for specific applications, such as cell culture. Microplate handling systems are available for laboratories seeking to improve workflows in areas such as high-throughput screening, next-generation sequencing, cellular analysis, PCR and assay set-up, serial dilutions, toxicology, plate labeling, and more.