Agilent MS RapidFire 300 High-throughput Mass Spectrometry System HP Rapid Fire

HP / Agilent


Sorry, this item is out of stock

Web Information

The RapidFire 300 High-throughput MS System, a robust, in-line solid phase extraction technology, delivers ultra-fast, label-free analysis of native compounds for biochemical assays in ADME and lead discovery workflows; and biological matrices in clinical research applications and forensic toxicology*.

Providing throughput speeds of 6 to 10 seconds per sample with no up-front sample preparation, the RapidFire 300/MS system fully integrates with triple quadrupole mass spectrometers. The system integrates fast, serial, online sample purification with triple quadrupole, TOF or Q-TOF mass spectrometric analysis.

Its flexible plate mapping, automated 6-cartridge changer and optical sensors to detect fluid flow, enable researchers to operate the system unattended, overnight or for long durations. Especially suited for pharmaceutical drug discovery and clinical research laboratories, RapidFire delivers lower cost per well and increased productivity.

An Overview of RapidFire Technology

RapidFire is a SPE-based, front-end system that enables detection of native compounds by mass spec. Requiring no labels or surrogates, it enables the screening of intractable or challenging targets which are not amenable to fluorescence or luminescence.  Sample throughput is 10x faster than conventional MS screening methods. Featuring fast and easy conversion, you can use Agilent’s RapidFire and conventional HPLC on a single mass spectrometer.

RapidFire technology provides researchers with shortened time to results, accurate data and greater potential for success.


  • 6 to 10 seconds per sample
  • Label-free analysis of native compounds for functional biochemical assays
  • Direct measurement of multiple reaction products concurrently
  • Lower cost per well
  • Reduced method development time
  • Suitable for lead discovery, ADME, and clinical research applications (not intended for diagnostic purposes)
  • Achieves accurate sensitive mass spec results, with no fluorescence interference, no tags and no antibodies

With high speed microscale valves, multi-plate capacity, and walkaway automation, the throughput capabilities of the Agilent RapidFire system are unmatched. Reductions in processing time, scientist intervention, and solvent usage result in maximal laboratory efficiency.

The Agilent RapidFire system requires no up-front sample preparation. The system samples directly from quenched assay plates without the need for offline solid-phase extraction or any other sample de-salting or pre-processing.

Researchers generate fast, accurate and reproducible results without the use of surrogates, radioactivity, coupled assays or indirect measurements. The sequence-based injection of the RapidFire enables individual wells of each plate to be analyzed using separate mass spectrometric methods. The system can accommodate up to eighteen standard 96 or 384 well plates.

Video overview:


      Seller refurbished. Instrument removed from a working environment. Unit passes built-in functional tests and range of motion calibration.

      See a video of this instrument in operation:


      (1) Agilent MS RapidFire 300 Hight-throughput Mass Spectrometry System consisting of:

      • Mobile Rapidfire cabin on wheels
      • Motion control computer
      • Digital peristaltic pump
      • Uninterruptible power supply
      • Sipper system
      • Twister microplate handler
      • additional accessories and consumables
      • One Agilent IDP-3 vacuum pump

      NOTE: This system is designed to integrate fast, serial, online sample purification with triple quadrupole, TOF or Q-TOF mass spectrometric analysis. Degasser, Fluidic Pumps and Mass spectrometer are NOT included as part of this sale.


      With your purchase, we offer the option for custom, white glove, delivery of the instrument from our warehouse to your laboratory within the continuous 48 states. Our courier will deliver and place the instrument at your desired location. This service is offered at no additional expense beyond the standard shipping charge for the item.

      Please note, our courier team is very busy delivering quality instruments with a smile! If you choose the white glove delivery option, we will schedule your item for delivery as soon as possible.


            30 Day warranty. We pledge to offer the best service and warranty to all of our customers!  We are extending a 30 Day warranty on this item. This is our way of saying thank you for allowing us to serve you.


            This is a genuine product from this manufacturer.